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Abundant expression of cytokeratin 7 in fibrolamellar carcinoma of the liver
Author(s) -
EYKEN P. VAN,
SCIOT R.,
BROCK P.,
DAELE M. CASTEELSVAN,
RAMAEKERS F.C.S.,
DESMET V.J.
Publication year - 1990
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1990.tb00679.x
Subject(s) - cytokeratin , pathology , immunohistochemistry , metastasis , carcinoma , blot , hepatocellular carcinoma , biology , lymph node , cancer research , medicine , cancer , gene , biochemistry , genetics
Two cases of fibrolamellar carcinoma of the liver, one with lymph node metastasis are reported. Using immunohistochemistry as well as one‐ and two‐dimensional gel electrophoresis and Western blotting, tumour cells of both primary lesions and of the metastasis were found to express cytokeratin polypeptides 8 and 18 and, surprisingly, cytokeratin 7. A small number of cells also expressed cytokeratin 19. This is the first detailed analysis of the cytokeratin expression of fibrolamellar carcinoma, and is also the first to present biochemical evidence that, contrary to what has been suggested, hepatocellular carcinomas do not always preserve the pattern of cytokeratin expression of normal hepatocytes.