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Clear cell metaplasia of the breast: A lesion showing eccrine differentiation
Author(s) -
Viña M.,
Wells C. A.
Publication year - 1989
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1989.tb03044.x
Subject(s) - mucin , metaplasia , pathology , epithelium , mammary gland , eccrine sweat gland , biology , medicine , sweat gland , sweat , breast cancer , cancer
Clear cell metaplasia of the human breast is known to be a benign metaplastic change which has no pre‐malignant connotation. Despite its proposed relationship to focal lactational change and to lactating breast, morphological and immunocytochemical features failed to demonstrate a clear relationship between these. Mucin secretion showed a characteristic pattern of granularity, and endocrine differentiation was not present. The mucin and immunocytochemical features suggest a relationship with eccrine sweat glands and a better name would perhaps be “eccrine metaplasia” to underline the special relationship breast metaplasias have to sweat gland epithelium.