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Immunohistochemical detection of the c‐erbB‐2 proto‐oncogene product in normal, benign and malignant cartilage tissues
Author(s) -
Wrba F.,
Gullick W. J.,
Fertl H.,
Amann G.,
SalzerKuntschik M.
Publication year - 1989
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1989.tb03042.x
Subject(s) - immunohistochemistry , cartilage , pathology , chondrosarcoma , malignant transformation , staining , oncogene , biology , medicine , cell , anatomy , cell cycle , genetics
Benign and malignant cartilage tumours as well as normal cartilage were stained immunohistochemically with antibodies raised to a synthetic peptide from the sequence of the c‐erbB‐2 protein. Positive staining was present in 18/23 of the chondrosarcomas and in one case of osteochondroma. Normal and benign neoplastic cartilage tissues revealed negative results. It is concluded that expression of the c‐erbB‐2 protein may contribute to cell transformation in chondrosarcomas; it is not apparent whether the expression of c‐erbB‐2 protein in chondrosarcomas characterizes a subpopulation of different prognostic significance.