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The prognostic significance of immunophenotype in high‐grade non‐Hodgkin's lymphoma
Author(s) -
BROWN D. C.,
HERYET A.,
GATTER K. C.,
MASON D. Y.
Publication year - 1989
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1989.tb02203.x
Subject(s) - immunophenotyping , lymphoma , medicine , pathology , b cell , antigen , large cell , antibody , non hodgkin's lymphoma , t cell , oncology , immunology , cancer , immune system , adenocarcinoma
The prognostic value of immunophenotyping lymphomas was assessed by studying 51 cases of high‐grade non‐Hodgkin's lymphoma for which long term clinical follow‐up (14–28 years) was available. Using antibodies which identify T‐ and B‐cell‐related antigens in formalin‐fixed, paraffin‐embedded material, 43 were shown to be of B‐cell and eight of T‐cell phenotype. In terms of survival, cases of high‐grade T‐cell lymphoma fared significantly worse ( P < 0.05) than cases of high‐grade B‐cell subtype. These findings support the belief that T‐cell lymphomas have a more aggressive clinical course than their B‐cell counterparts.