Premium
Hamartomas of the spleen: a study of 20 biopsy cases
Author(s) -
FALK S.,
STUTTE H. J.
Publication year - 1989
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1989.tb02201.x
Subject(s) - spleen , medicine , biopsy , pathology
Twenty hamartomas of the spleen were studied by histological, immuno‐ and enzyme‐histochemical methods. In all cases nodules of varying size resembling proliferation of splenic red pulp structures were present that exhibited considerable morphological variation with regard to plasmacytosis, extramedullary haematopoiesis and phagocytic activity of macrophages. Splenic red pulp structures could be identified by immuno‐ and enzyme‐histochemical markers reacting with sinus endothelium, including Factor VIII related antigen, proteinase inhibitors and nonspecific esterases. In conjunction with the absence of organized lymphoid tissue and of dendritic reticulum cells these studies allow the differentiation of splenic hamartomas from haemangiomas that may possess a deceptively similar morphological appearance.