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Cytokeratin expression in cervical epithelium: an immunohistological study of normal, wart virus‐infected and neoplastic tissue
Author(s) -
WHITTAKER J. R.,
SAMY A. M. J.,
SUNTER J. P.,
SINHA D. P.,
MONAGHAN J. M.
Publication year - 1989
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1989.tb02125.x
Subject(s) - staining , squamous metaplasia , pathology , cytokeratin , epithelium , immunohistochemistry , biology , stratified squamous epithelium , squamous carcinoma , cervix , metaplasia , carcinoma , medicine , cancer , genetics
In this study using a panel of anticytokeratin antibodies and an indirect immunoper‐oxidase method, we examined cervical squamous epithelia including mature stratified epithelium, immature squamous metaplasia, CIN 1, 2 and 3, wart virus infection and squamous carcinoma. Changes from the normal patterns of staining were inconsistently seen in CIN 1 and 2, but in CIN 3 the changes were more marked, and consisted of a loss of stratification of the staining pattern and a patchy reduction in staining. Invasive carcinomas showed a similar staining pattern to CIN 3 lesions.