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Immunoreactive cytokeratins in plasmacytomas
Author(s) -
WOTHERSPOON A. C.,
NORTON A. J.,
ISAACSON P. G.
Publication year - 1989
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1989.tb02124.x
Subject(s) - cytokeratin , plasmacytoma , antibody , pathology , multiple myeloma , plasma cell , biology , immunohistochemistry , medicine , immunology
Fourteen plasma cell tumours, including examples of solitary plasmacytoma and multiple myeloma, were studied with a panel of antibodies reactive in formalin‐fixed, paraffin wax‐embedded tissue. Each case showed immunoglobulin light chain restriction. Five tumours were reactive with antibodies to cytokeratin. Of these five cases, four were negative with antibodies to leucocyte common antigen and only one was weakly positive. Anti‐cytokeratin reactivity by plasma cell tumours is more common than was originally anticipated and represents an important diagnostic pitfall.