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Oestrogen receptors in benign epithelial lesions and intraduct carcinomas of the breast: an immunohistological study
Author(s) -
GIRI D. D.,
C.DUNDAS S. A.,
NOTTINGHAM J. F.,
E.UNDERWOOD J. C.
Publication year - 1989
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1989.tb01623.x
Subject(s) - myoepithelial cell , pathology , apocrine , immunohistochemistry , staining , comedo , carcinoma , cribriform , estrogen receptor , lobular carcinoma , epithelium , fibroadenoma , mammary gland , medicine , biology , ductal carcinoma , breast cancer , cancer
We examined 198 breast lesions, representing commonly encountered benign epithelial proliferative disorders, lobular carinoma in situ and intraduct carcinoma, immunohistologically for oestrogen receptors (ER). A mixture of three ER monoclonal antibodies—H222, D75 and D547—was used on sections of routinely processed and paraffin‐embedded tissue blocks. Over 65% of the benign and malignant lesions showed some evidence of ER expression and significant staining was recorded by two observers in 28–31% of fibroadenomas, 18–28% of ductal epithelial hyperplasias, 30–40% of sclerosing adenosis cases, 38–45% of papillomas, 60% of in situ lobular carcinomas and 42–45% of intraduct carcinomas. Apocrine metaplastic cells and myoepithelial cells showed absent or only weak staining. Amongst intraduct carcinomas, less than 20% of comedo carcinomas and over 50% of cribriform, papillary and solid variants showed significant ER staining.