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Penicillium marneffei infection: an underdiagnosed disease?
Author(s) -
TSANG D. N. C.,
CHAN J. K. C.,
LAU Y. T.,
LIM W.,
TSE C. H.,
CHAN N. K.
Publication year - 1988
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1988.tb02041.x
Subject(s) - penicillium marneffei , hepatosplenomegaly , pathology , penicillium , medicine , epithelioid cell , biopsy , tuberculosis , infiltration (hvac) , disease , immunology , dermatology , biology , human immunodeficiency virus (hiv) , immunohistochemistry , coinfection , physics , genetics , thermodynamics
Penicillium marneffei is a rare human pathogen that often causes problems in clinical and histological diagnosis. A patient who presented with autoimmune haemolytic anaemia and hepatosplenomegaly, and was subsequently found to be suffering from disseminated Penicillium marneffei infection, is reported. The liver biopsy showed epithelioid cell granulomas only, and tuberculosis was initially considered the most likely diagnosis. The correct diagnosis became evident in a subsequent colonic biopsy, which showed extensive infiltration by penicillium‐laden macrophages.