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Genesis and decay of the foregut: development and repair
Author(s) -
VILANOVA J. R.,
SIMONMARIN R.,
ANGULO J. C.,
RIVERAPOMAR J. M.
Publication year - 1988
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1988.tb02038.x
Subject(s) - foregut , metaplasia , intestinal metaplasia , biology , phenotype , anatomy , atrophic gastritis , pathology , neuroscience , stomach , medicine , cancer , gastritis , genetics , gene , biochemistry
The microscopic anatomy of the oesophago‐gastric territory is interpreted as the result of the interaction of three main phenotypes: squamous, oxyntic and intestinal. This synthesis allows the comparison between phenotype development, atrophy and metaplasia. The concomitances in the processes of development and repair lead to the proposal of an intestinalization gradient inherent to the oesophago‐gastric field. This hypothesis permits an integration of the epithelial changes associated with gastritis and oesophagitis together with ontogenesis. The global tendencies in epithelial development and repair are discussed; a link between the two appears evident. The shifting potential of the progenitor gland zones in development and repair is in consonance with Wolpert's theory of positional information.