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Nucleolar organizer regions in melanocytic dysplasia and melanoma
Author(s) -
FALLOWFIELD M. E.,
DODSON A. R.,
COOK M. G.
Publication year - 1988
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1988.tb02007.x
Subject(s) - melanoma , nucleolus organizer region , dysplasia , pathology , medicine , dermatology , biology , cancer research , nucleolus , genetics , cytoplasm
Using silver (Ag) staining to demonstrate nucleolar organizer region‐associated proteins (AgNORs), pigmented naevi exhibiting features of melanocytic dysplasia have been examined and compared with benign intradermal and compound naevi and with malignant melanomas. A highly significant difference was found between the numbers of AgNORs demonstrated in benign naevus cells and atypical melanocytes and in malignant melanocytes, suggesting that this technique may have a role in differentiating between difficult melanocytic lesions.