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Architectural morphometry in ulcerative colitis with dysplasia
Author(s) -
ALLEN D. C.,
HAMILTON P. W.,
WATT P. C. H.,
BIGGART J. D.
Publication year - 1988
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1988.tb01985.x
Subject(s) - muscularis mucosae , dysplasia , pathology , ulcerative colitis , lamina propria , grading (engineering) , medicine , epithelium , submucosa , intestinal mucosa , biology , disease , ecology
Semi‐automatic image analysis was used to assess the architectural features of normal colorectal mucosa and ulcerative colitis with and without dysplasia. Eight measured and derived morphometric variables were compared with the histological grading. The main data‐set variation was due to: (1) the area of mucosa and epithelium per unit length of muscularis mucosae; (2) mean mucosal and epithelial height; and (3) the percentage epithelium and number of crypts per unit length of muscularis mucosae. Discriminant analysis using the variables mean epithelial height and mean lamina propria area per unit length of muscularis mucosae separated normals ( n =10) from high‐grade dysplasia (8). The classification rule allocated low‐grade dysplasia (8) to the high‐grade category and 60% of regeneration cases (10) to the normal mucosa group. Scatter plots of the two discriminating variables separated normal and regenerative mucosa from dysplasia. Histological review of overlapping cases allowed redesignation of a high‐grade dysplasia lesion as low grade. Architectural morphometry may be of use in assessing premalignant mucosal changes in ulcerative colitis as a guide to patient surveillance and therapy.