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Testicular atrophy after oestrogen therapy
Author(s) -
VENIZELOS I. D.,
PARADINAS F. J.
Publication year - 1988
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1988.tb01961.x
Subject(s) - atrophy , sertoli cell , testicular atrophy , spermatogenesis , histology , medicine , prostate , endocrinology , biology , urology , gynecology , cancer
Therapeutic use of oestrogens by males with carcinoma of the prostate leads to testicular atrophy with markedly reduced spermatogenesis after only 21 d (Oshima et al. 1974). Treatment for over a year results in paucity of germ cells, vacuolation of Sertoli cells and reduction in Leydig cells (Lu & Steinberger 1978, Smith & Urry 1985). There is, apparently, no information on the histology of the human testis after more than 1 year oestrogen therapy. We here report changes in testes from five transsexuals treated for periods of up to 5.5 years.