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Granular cell tumours revisited. An immunohistological and ultrastructural study
Author(s) -
BULEY I.D.,
GATTER K.C.,
KELLY P.M.A.,
HERYET A.,
MILLARD P.R.
Publication year - 1988
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1988.tb01941.x
Subject(s) - ultrastructure , pathology , biology , medicine
Twenty‐five granular cell tumours were stained with a panel of antibodies to histiocytic, muscle, neural, neural crest, epithelial and endothelial markers. Electron microscopy was also performed in six cases. Twenty‐four of the cases were similar morphologically and immunocytochemically. One case with features of an endothelial origin is described. The present study strongly supports the viewpoint that granular cell tumours are a distinct entity rather than being the common appearance of a group of lesions of differing histogenesis. Origin from a neural crest‐derived peripheral nerve‐related cell is favoured.