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Fibrous hamartoma of infancy: a histochemical and immunohistochemical study
Author(s) -
FLETCHER C.D.M.,
POWELL G.,
NOORDEN S.,
McKEE P.H.
Publication year - 1988
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1988.tb01917.x
Subject(s) - histogenesis , hamartoma , immunohistochemistry , pathology , lesion , vimentin , mucin , anatomy , medicine
Fibrous hamartoma of infancy is an uncommon lesion, the histogenesis and biological nature of which are uncertain. Ten cases have been studied by light microscopy, mucin histochemistry and immunohistochemistry. The typical histological features are presented. The presence of hyaluronic acid and of chondroitin‐4‐ and ‐6‐sulphate and keratan sulphate has been demonstrated in different components of the tumour. Vimentin positivity was noted in the undifferentiated and fibroblastic components. The implications of these findings are discussed. Whether the lesion merits the designation of hamartoma or is, in fact, a benign neoplasm remains obscure.