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Ultrastructure of early plexogenic pulmonary arteriopathy
Author(s) -
HEATH D.,
SMITH P.,
GOSNEY J.
Publication year - 1988
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1988.tb01915.x
Subject(s) - enteroendocrine cell , pathology , ultrastructure , pulmonary hypertension , myocyte , medicine , lung , smooth muscle , electron microscope , biopsy , anatomy , pulmonary vasculature , endocrine system , hormone , optics , physics
A lung biopsy specimen from a young woman with the clinical features of primary pulmonary hypertension showed grade 2 plexogenic pulmonary arteriopathy. Electron microscopy revealed ‘dark’, electron‐dense smooth muscle cells in the inner part of the media of muscular pulmonary arteries. Many of these transformed myocytes had migrated into the lumens of pulmonary arteries and arterioles which they occluded. This migration of smooth muscle cells was associated with a substantial increase in the number of pulmonary endocrine cells in the bronchioles containing bombesin and calcitonin.