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Malignant rhabdoid tumour of soft tissue. An ultrastructural and immunohistological study of a pelvic tumour
Author(s) -
DERVAN P.A.,
CAHALANE S.F.,
KNEAFSEY P.,
MYNES A.,
MCALLISTER K.
Publication year - 1987
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1987.tb02621.x
Subject(s) - vimentin , pathology , desmin , cytokeratin , rhabdomyosarcoma , intermediate filament , immunohistochemistry , biology , ultrastructure , sarcoma , cytoplasm , neurofilament , electron microscope , enolase , staining , cytoskeleton , medicine , cell , microbiology and biotechnology , genetics , physics , optics
A case of extrarenal malignant rhabdoid sarcoma arising in the pelvic soft tissues of a 12‐year‐old girl is described. By routine light microscopy the tumour resembled, in some areas, an embryonal rhabdomyosarcoma and, in other areas, a neuroblastoma. Electron microscopy revealed characteristic cytoplasmic aggregates of intermediate filaments, often with central clusters of organelle membranes surrounded by these filament. Immunohistochemical stains showed strong cytoplasmic reactivity for vimentin. Staining for cytokeratin, myoglobin, desmin, neurofilaments, neurone specific enolase, S‐100 protein and leucocyte common antigen was negative. A histogenetic origin from primitive mesenchymal cells is favoured. We strongly support the use of electron microscopy for the definitive diagnosis of small round cell undifferentiated sarcomas of childhood.