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S‐100 protein: a prognostic indicator in cutaneous malignant melanoma?
Author(s) -
KERNOHAN N.M.,
RANKIN R.
Publication year - 1987
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1987.tb01873.x
Subject(s) - melanoma , breslow thickness , medicine , incidence (geometry) , pathology , immunohistochemistry , anatomical pathology , oncology , dermatology , cancer , sentinel lymph node , physics , cancer research , breast cancer , optics
A series of 215 cases of cutaneous malignant melanoma referred to a single department of clinical oncology between 1940 and 1969 was studied to assess the accuracy of the Breslow thickness and the role of S‐100 protein in predicting the clinical prognosis. Histological examination of these tumours showed that although the Breslow thickness correlated well with prognosis, in a significant number of cases it did not reliably forecast clinical outcome. From this series, tissue from those patients who survived disease‐free for more than 10 years and those who died within a year of diagnosis was stained immunohistochemically for S‐100 protein. Contrary to the findings of earlier studies, strong staining for S‐100 protein was associated with improved survival ( P <0.001). A marked increase in the incidence of cutaneous malignant melanoma was noted during the period of the study.