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Low‐grade lymphoma of immature T‐cell phenotype in a case of lymphocytic interstitial pneumonia and Sjögren's syndrome
Author(s) -
SCHUURMAN H.J.,
GOOSZEN H.CH.,
TAN I.W.N.,
KLUIN P.M.,
WAGENAAR SJ.SC.,
UNNIK J.A.M. VAN
Publication year - 1987
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1987.tb01859.x
Subject(s) - pathology , cd5 , lymphoma , medicine , lymph node , malignancy , cd30
A 19–year‐old male patient presented with lymphocytic interstitial pneumonia and Sjögren's syndrome, confirmed by histopathology. He was treated with prednisone; 4 months later, cyclophosphamide was added. A lymph node taken at presentation revealed no histological signs of malignancy. Lymph nodes obtained 1 and 2 years later exhibited an effaced structure and a diffuse infiltration of small‐sized lymphocytic cells compatible with a low‐grade non‐Hodgkin's lymphoma. The immunological phenotype of the lymphoma resembled that of immature T‐cells present in the normal thymus cortex—positivity for CD1, CD2, CD4, CD7, CD38 and terminal deoxynucleotidyl transferase; faint positivity for CD5 and in the second specimen for CD3; negativity for CD6 and MHC class 1 antigen. The occurrence of such a peculiar lymphoma in Sjögren's syndrome has not been reported thus far. Small numbers of putative malignant cells were found on immunohistochemistry in a lymph node and a lung biopsy obtained at presentation. This is suggestive of one underlying pathogenetic event in the development of lymphocytic interstitial pneumonia, Sjögren's syndrome and non‐Hodgkin's lymphoma.