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Liver findings in infantile cytomegalovirus infection: similarity to extrahepatic biliary obstruction
Author(s) -
LURIE M.,
ELMALACH I.,
SCHUGER L.,
WEINTRAUB Z.
Publication year - 1987
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1987.tb01857.x
Subject(s) - cholestasis , cytomegalovirus , cytomegalovirus infection , medicine , bile duct , biliary tract , hepatitis , gastroenterology , pathology , betaherpesvirinae , human cytomegalovirus , herpesviridae , virus , viral disease , immunology
The histological findings in the liver in four fatal cases of infantile cytomegalovirus (CMV) infection are presented, three occurred in premature infants, and all died at the ages of 2–4 months. Most previously reported cases showed various degrees of hepatitis with giant cell transformation. In three of our four cases, however, the main feature was cholestasis, portal fibrosis and bile duct proliferation, not unlike the findings seen in extrahepatic biliary obstruction. In one case, massive hepatic necrosis was found, a finding not previously reported in this disease. The diversity of liver findings in infantile CMV infection is stressed.