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Cerebral infarction due to systemic necrotizing vasculitis in a patient with rheumatic heart disease, subacute bacterial endocarditis and status epilepticus
Author(s) -
MIZUTANI T.,
YOSHIMURA K.,
MATSUSHITA H.,
SHIOZAWA R.,
HARA M.
Publication year - 1987
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1987.tb01848.x
Subject(s) - medicine , vasculitis , endocarditis , subacute bacterial endocarditis , myocarditis , systemic vasculitis , autopsy , necrotizing vasculitis , brain abscess , heart disease , mitral valve , rheumatic fever , infective endocarditis , cardiology , abscess , surgery , disease
Systemic necrotizing vasculitis involving cerebral blood vessels is described in a 30‐year‐old man with rheumatic heart disease and subacute bacterial endocarditis. Fever, anaemia, splenomegaly and positive blood cultures for Gram‐negative bacteria were found on admission. The fever resolved with antibiotic therapy on the third hospital day but he then developed hemiplegia and multifocal seizures. The seizures progressed to uncontrollable status epilepticus accompanied by congestive heart failure and the patient died 20 d after admission. At autopsy, exudative and necrotizing vasculitis involving medium‐ to small‐sized arteries was seen in the brain, the heart and the skeletal muscles. Rheumatic myocarditis and endocarditis and old rheumatic mitral valve deformities were also present. In addition, verrucous endocarditis in the mitral valve and Löhlein's focal glomerulonephritis were noted. We discuss the possible mechanism of the systemic necrotizing vasculitis in relation to rheumatic fever.