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Distribution of basement membrane laminin and type IV collagen in human reactive lymph nodes
Author(s) -
KARTTUNEN T.,
ALAVAIKKO M.,
APAJASARKKINEN M.,
AUTIOHARMAINEN H.
Publication year - 1986
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1986.tb02582.x
Subject(s) - basement membrane , reticular fiber , reticular connective tissue , laminin , pathology , lymph , type iv collagen , anatomy , staining , parenchyma , marginal zone , reticular cell , lymph node , basement , biology , chemistry , medicine , microbiology and biotechnology , extracellular matrix , antibody , immunology , spleen , civil engineering , engineering , b cell
The location of two basement membrane components, laminin and the 7‐S domain of type IV collagen, was studied in human lymph nodes using the peroxidase‐antiperoxidase method. Basement membrane antigens were present on the walls of blood vessels and of marginal, trabecular and medullary sinuses. Thin, fragmented fibre‐like staining was present also in parenchyma outside the germinal centres, in a pattern overlapping with reticular fibres as seen on conventional reticulin stains. This finding suggests that basement membrane components are a part of the reticular fibres of lymph nodes, or are closely associated with them.