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Demonstration of S‐100 protein in sustentacular cells of phaeochromocytomas and paragangliomas
Author(s) -
SCHRODER H. D.,
JOHANNSEN L.
Publication year - 1986
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1986.tb02539.x
Subject(s) - paraganglioma , pathology , immunohistochemistry , glial fibrillary acidic protein , gastric chief cell , adrenal medulla , medicine , pheochromocytoma , biology , anatomy , endocrinology , catecholamine , stomach , gastric mucosa
Eighteen phaeochromocytomas, including both sporadic and familial cases, four cervical paragangliomas, two jugular paragangliomas, and one abdominal paraganglioma were examined immunohistochemically for the presence of 5–100 protein. Positive staining in cells morphologically similar to the sustentacular cells of normal paraganglia and adrenal medulla were found in all paragangliomas and in the benign and aggressively growing phaeochromocytomas. In the two malignant tumours no positive reaction was demonstrated. In one tumour the sustentacular cells were shown to contain glial fibrillary acidic protein further supporting their Schwann cell relationship. The number of 5–100 positive cells varied considerably. They demonstrated a spindle celled or elongated configuration with long slender processes. The nature of the sustentacular cell proliferation, neoplastic versus reactive, is discussed.