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Gastric signet‐ring cell lymphoma with alpha heavy chains
Author(s) -
TUNGEKAR M. F.
Publication year - 1986
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1986.tb02526.x
Subject(s) - signet ring cell , signet ring cell carcinoma , lymphoma , pathology , stomach , gastric lymphoma , medicine , cancer , adenocarcinoma
Signet‐ring cell lymphomas are rare especially as primary gastric tumours; alpha chain disease of the stomach is also unusual. A case of gastric signet‐ring cell lymphoma with free alpha chains in the gastro‐duodenal juice is reported and its light microscopic, immunohistological and ultrastructural features are described. Although the morphogenesis of signet‐ring cell lymphoma is not clear, the present case showed many of the features of a mucosa‐associated lymphoma. This rare variant of follicle centre cell lymphoma may easily be mistaken for a signet‐ring cell carcinoma. A search for abnormal immunoglobulins should be made in serum, secretions or tissues in future cases of signet‐ring cell lymphoma.