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Basement membrane proteins in the spleen: immunohistochemical demonstration and relation to reticulin
Author(s) -
APAJASARKKINEN M.,
ALAVAIKKO M.,
KARTTUNEN T.,
AUTIOHARMAINEN HELENA
Publication year - 1986
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1986.tb02483.x
Subject(s) - basement membrane , reticular connective tissue , reticular fiber , spleen , pathology , immunohistochemistry , laminin , reticular cell , stain , type iv collagen , staining , anatomy , biology , medicine , microbiology and biotechnology , extracellular matrix , immunology
In the present study imunohistochemical staining has shown that the ring fibres of the human spleen contain the major basement membrane components, type IV collagen and laminin. The superiority of immunohistochemical methods in demonstrating basement membrane material in the spleen is emphasized. The results are compared with the demonstration of reticular fibres by Gomori's reticulin stain. The findings provide further information about the relationship between basement membrane material and reticular fibres in human spleen. The nature of splenic ring fibres is discussed in the light of the scientific literature.