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Fibrinogen inclusions in liver cells: a new type of ground‐glass hepatocyte. Immune light and electron microscopic characterization
Author(s) -
CALLEA F.,
VOS R.,
TOGNI R.,
TARDANICO R.,
VANSTAPEL M. J.,
DESMET V. J.
Publication year - 1986
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1986.tb02461.x
Subject(s) - endoplasmic reticulum , hepatocyte , cytoplasm , electron microscope , fibrinogen , staining , intracellular , pathology , biology , chemistry , microbiology and biotechnology , medicine , biochemistry , optics , physics , in vitro
A new type of ground‐glass hepatocyte is described. The appearance is due to pale, homogeneous, weakly eosinophilic inclusions filling a portion of or the entire hepatocytic cytoplasm. On haematoyxlin and eosin stained sections, these cells closely resemble ground‐glass hepatocytes described in other conditions. However, they are negative on special stains for HBsAg and on PAS staining. Immunohistochemically, they reveal a selective and exclusive positivity for fibrinogen. On electron microscopy, the immunoreactive fibrinogen appears as amorphous, fluffy or granular material within dilated cisternae of the rough endoplasmic reticulum. This finding suggests intracellular storage possibly reflecting a defective intracellular transport of fibrinogen.