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The organization of cell populations within lymph nodes: their origin, life history and functional relationships
Author(s) -
FOSSUM S.,
FORD W. L.
Publication year - 1985
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1985.tb02830.x
Subject(s) - lymph , evolutionary biology , biology , pathology , medicine
The normal lymph node comprises a superficial cortex, a deep cortex or paracortex and a medulla. In each of these regions there are three kinds of spaces: an intralymphatic space, an intravascular space and an extravascular space or interstitium. Both the vascular endothelium and the lymphatic endothelium are specialized in these different regions. The cell types in lymph nodes comprise lymphoid cells, accessory or non‐lymphoid cells and stromal cells, and within these cell types a number of different sub‐types can now be identified by means of enzyme‐ and immunocytochemistry. Based predominantly on experimental studies, the origin, migratory patterns, localization, inter‐relationships and interactions between these various cells are reviewed.