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Liver cell dysplasia and hepatocellular carcinoma: a histoiogical and immunohistochemical study
Author(s) -
RONCALLI M.,
BORZIO M.,
BIAGI G.,
SERVIDA E.,
CANTABONI A.,
SIRONI M.,
TACCAGNI G.L.
Publication year - 1985
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1985.tb02436.x
Subject(s) - hepatocellular carcinoma , cirrhosis , hbsag , dysplasia , pathology , immunohistochemistry , antigen , liver cell , carcinoma , medicine , alpha fetoprotein , biology , cancer research , hepatitis b virus , immunology , virus
Liver cell dysplasia (LCD) was found in 28 (60%) of 47 patients with hepatocellular carcinoma (HCC); 22 (79%) of them had associated liver cirrhosis. LCD was more frequently observed in posthepatitic cirrhosis (82%) than in the other forms. Carcino‐embryonic antigen (CEA), alpha‐ 1‐antitrypsin (AAT) and alpha‐fetoprotein (AFP), as demonstrated by the peroxidase‐antiperoxidase method, were similarly expressed both in normal and in dysplastic cells. Hepatitis B surface antigen was found in eight cases (17%), six of which were associated with LCD. HBsAg was rarely found in dysplastic cells and frequently displayed a peculiar perinuclear pattern. The possible preneoplastic role of LCD is stressed.