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Coeliac disease: alpha‐1‐antitrypsin contents in jejunal mucosa before and after gluten‐free diet
Author(s) -
NIELSEN KARSTEN
Publication year - 1984
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1984.tb02392.x
Subject(s) - coeliac disease , jejunum , gluten free , gastroenterology , gluten , intestinal mucosa , immunohistochemistry , medicine , pathology , immunopathology , alpha 1 antitrypsin deficiency , intestinal malabsorption , alpha (finance) , disease , biology , surgery , construct validity , patient satisfaction
Biopsies of the jejunum from 10 patients suffering from coeliac disease were investigated by an immunohistochemical technique for α‐1‐antitrypsin. The biopsies obtained before treatment did not contain α‐1‐antitrypsin, but after a gluten‐free diet α‐1‐antitrypsin was present in Paneth cells in the mucosal crypts. This finding suggests that the absence of α‐1‐antitrypsin in the jejunal mucosa might be a pathogenetic factor in coeliac disease.