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Silicotic lesions of the bone marrow: histopathology and microanalysis
Author(s) -
EIDE J.,
GYLSETH B.,
SKAUG V.
Publication year - 1984
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1984.tb02381.x
Subject(s) - histopathology , pathology , bone marrow , silicosis , medicine , microanalysis , chemistry , organic chemistry
Silica deposition and characteristic nodular silicotic lesions of the bone marrow, virtually unknown features of silicosis, are described in a case of severe lung silicosis with silicotic granulomas of the liver and spleen. Scanning electron microscopy and X‐ray microanalysis confirmed the presence of quartz and feldspars. The bone marrow lesions included inconspicuous accumulations of silica‐containing macrophages, free silica, slight lymphocyte and plasma cell infiltration, and reticulin fibre formation; and development of slightly larger partly fibrous silicotic nodules, comparable to those of the lung, liver, and spleen. Silicosis must therefore be considered in the differential diagnosis of bone marrow granulomas.