Premium
Immunohistological differential diagnosis of inflammatory colonic diseases
Author(s) -
SCHNEIDER H.M.,
LOOS M.,
STÖRKEL S.,
GROSS M.
Publication year - 1984
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1984.tb02370.x
Subject(s) - ulcerative colitis , colitis , medicine , intestinal mucosa , inflammatory bowel disease , antibody , pathology , pathogenesis , crohn's disease , immunology , disease
Immunohistological investigations were carried out on human colonic tissue from, 1 healthy mucosa, 2 slightly inflamed mucosa, 3 mucosa with ulcerative colitis, 4 mucosa with Crohn's colitis, using antibodies against immunoglobulins and complement components. All our antibodies, including F(ab’) 2 fragments, demonstrated a progressive increase of labelled cells from healthy mucosa through slightly inflamed mucosa to mucosa with ulcerative colitis, in contrast to a complete absence of labelled cells in cases of Crohn's disease. The results are discussed with regard to their pathogenesis and their clinical significance for the differentiation of ulcerative colitis and Crohn's colitis.