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An immunohistological study of benign and skin tumours: epithelial aspects
Author(s) -
GATTER K.C.,
PULFORD K.A.F.,
VANSTAPEL M.J.,
ROACH B.,
MORTIMER P.,
WOOLSTON R.E.,
TAYLORPAPADIMITRIOU J.,
LANE E.B.,
MASON D.Y.
Publication year - 1984
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1984.tb02337.x
Subject(s) - monoclonal antibody , keratoacanthoma , antigen , pathology , immunohistochemistry , basal cell carcinoma , basal cell , biology , antibody , pathogenesis , differential diagnosis , carcinoma , monoclonal , cell , medicine , immunology , genetics
Biopsies of normal skin and benign and malignant skin tumours were studied immunohistologically with nine monoclonal antibodies. The study showed that monoclonal antibodies can clearly delineate antigens expressed in different regions of normal skin and that, in general, tumours retain the antigenic pattern characteristic of the region from which they have arisen. These findings indicate the potential value of analysing these patterns of antigenic expression with a panel of monoclonal antibodies both for understanding the pathogenesis of skin tumours (e.g. basal cell carcinomas) and in their differential diagnosis (e.g. squamous cell carcinoma versus keratoacanthoma).