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Chronic duodenitis with gastric metaplasia: electron microscopic study including comparison with normal
Author(s) -
SHOUSHA S.,
PARKINS R.A.,
BULL T.B.
Publication year - 1983
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1983.tb02302.x
Subject(s) - duodenitis , intestinal metaplasia , glycocalyx , pathology , gastroenterology , metaplasia , medicine , duodenum , electron microscope , duodenal diseases , mucus , stomach , biology , gastritis , immunology , ecology , physics , optics
Dudoenal biopsies from 11 patients with non‐ulcer dyspepsia were examined by electron microscopy. Chronic duodenitis with gastric metaplasia was seen in samples from four patients, and areas of normal‐looking duodenal mucosa were present in nine. The metaplastic cells were similar to those previously described in association with duodenal ulcers. They usually showed marked morphological differences from the normal duodenal absorptive cells. The microvilli were distorted and reduced in number, the glycocalyx was ill‐defined, the cytoplasm filled with mucous globules and the intercellular spaces, in some areas, were widened and contained acute and chronic inflammatory cells.