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The immunocytochemical demonstration of renin in a juxtaglomerular cell tumour by light and electron microscopy
Author(s) -
LINDOP G.B.M.,
STEWART J.A.,
DOWNIE T.T.
Publication year - 1983
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1983.tb02255.x
Subject(s) - juxtaglomerular apparatus , electron microscope , renin–angiotensin system , immunocytochemistry , pathology , microscopy , medicine , endocrinology , physics , optics , blood pressure
This is a study of a juxtaglomerular cell tumour using an antibody to pure human renin and the peroxidase‐antiperoxidase technique. We report the distribution of immunoreactive renin in the tumour visualized by light microscopy of both paraffin and resin embedded tissue sections. We found that the cells which contained most renin granules were endocrine‐like cells in the parenchyma of the tumour. Ultrastructural immunocytochemistry showed that immunoreactive renin was present not only in crystalline protogranules and in round membrane bound granules, but also in intermediate forms.