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Large paraffin sections and chemical clearance of axillary tissues as a routine procedure in the pathological examination of the breast
Author(s) -
GIBBS N. M.
Publication year - 1982
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1982.tb02757.x
Subject(s) - medicine , malignancy , quadrant (abdomen) , breast carcinoma , lymph node , carcinoma , radiology , histology , carcinoma in situ , breast cancer , pathology , cancer
The technique of large paraffin sections of the breast and lymph node dissection of axillary tissues after chemical clearance as used in a routine histology laboratory is described and discussed. The findings in 155 cases of breast malignancy derived from routine surgical patients and also from the breast screening clinic are described and analysed. There were 21 cases of in‐situ carcinoma alone and an additional 17 cases with minimal invasive carcinoma (MIC). The maximum area of each lesion in one plane was measured and the size varied between < 1 cm 2 and 30 cm 2 , with an average of 7 cm 2 . The large lesions had the highest incidence of MIC. There were 117 palpable invasive carcinomas and they were divided into two groups, namely single quadrant (80%) and multiquadrant malignancy (20%). The clinical implications of this are discussed. Lymph node metastases were found in 36 (27%) of all invasive carcinomas but no metastases were found in either in‐situ carcinoma alone or when combined with MIC in the eight cases which had a radical operation.