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The ‘transitional’ mucosa adjacent to large bowel carcinoma—electron microscopic features and myofibroblast reaction
Author(s) -
BALÁZS MÁRTA,
KOVÁCS AGOTA
Publication year - 1982
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1982.tb02755.x
Subject(s) - myofibroblast , pathology , tunica , stromal cell , distension , carcinoma , biology , anatomy , chemistry , medicine , fibrosis
An electron microscopic study of the ‘transitional’ mucosa adjacent to 10 carcinomas of the colon showed impaired maturation of epithelial cells. The pericryptal fibroblast layer was absent, accounting for an increase in the length and distension of crypts. In the tunica propria a massive accumulation of myofibroblasts was noted and was indicative of an intensive fibre‐producing activity. Review of the literature identifies various theories concerning the functions of myofibroblasts in respect of contraction, embryonal collagen‐fibre formation and non‐specific stromal reaction. Of these, the latter two are considered likely in relationship to transitional colonic mucosa.