Premium
Alpha‐1‐antitrypsin immunoreactivity in gastric carcinoid
Author(s) -
RAY M. B.,
GEBOES K.,
CALLEA F.,
DESMET V. J.
Publication year - 1982
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1982.tb02723.x
Subject(s) - stomach , adenocarcinoma , pathology , alpha (finance) , carcinoid tumour , immunohistochemistry , medicine , carcinoma , enterochromaffin like cell , gastric mucosa , biology , gastroenterology , cancer , construct validity , nursing , patient satisfaction
Alpha‐1‐antitrypsin (AAT) was demonstrated in tumour cells in three out of five cases of gastric carcinoma showing the histological characteristics of carcinoid tumour. It was also detected in normal stomach mucosa, but was not found in 10 cases of adenocarcinoma of intestinal or mucous cell type. The AAT‐positive tumour cells were argyrophilic, PAS‐positive and were negative for pancreatic and gastric hormones. These findings suggest a possible malignant proliferation of alpha‐1‐antitrypsin‐containing cells in the stomach.