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Multiple endocrine neoplasia type 2b in twins
Author(s) -
GALERA H.,
GONZALEZCAMPORA R.,
MATILLA A.,
MARTIN I.
Publication year - 1982
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1982.tb02706.x
Subject(s) - multiple endocrine neoplasia , medullary cavity , thyroid carcinoma , medullary carcinoma , medicine , endocrine system , marfan syndrome , multiple endocrine neoplasia type 2 , pathology , thyroid , mutation , germline mutation , biology , genetics , hormone , gene
The syndrome of multiple endocrine neoplasia (MEN or MEA) type 2b is characterized by the association of medullary carcinoma of the thyroid, phaeochromocytoma, ganglioneuromatosis and Marfan‐like features. Though this disorder usually shows a familial distribution, it may also appear spontaneously as the result of a genetic mutation. This paper describes the second case of MEA type 2 in twins, and appears to be the first description in twins of the association of medullary carcinoma of the thyroid, Marfan‐like features and multiple neuromas.