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Atypical juvenile polyposis
Author(s) -
GRIGIONI W. F.,
ALAMPI G.,
MARTINELLI G.,
PICCALUGA A.
Publication year - 1981
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1981.tb01798.x
Subject(s) - hyperplastic polyp , dysplasia , hyperplasia , pathology , juvenile , adenoma , epithelium , medicine , biology , colonoscopy , colorectal cancer , cancer , genetics
Two cases of atypical juvenile polyposis are described in males of 9 months and 25 years‐of‐age. The first was associated with congenital megacolon and presented as juvenile polyps with features suggesting mild dysplasia. In the second case six histological lesions are found: 1 hyperplastic polyps; 2 juvenile polyps; 3 hyperplastic polyps with adenomatous areas; 4 juvenile polyps with areas of dysplastic epithelium; 5 adenomas; and 6 adenocarcinomas. On the basis of the morphological features we propose a pathogenetic sequence of focal mucosal hyperplasia to adenoma and carcinoma through stages of non‐neoplastic and non premalignant polyps. Finally, the possibility that hyperplastic epithelium can in some circumstances have a greater dysplastic potential than normal colorectal mucosa is raised.