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Immunoblastic sarcoma after thymus epithelial graft in an immunodeficient child
Author(s) -
DICTOR M.
Publication year - 1980
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1980.tb02962.x
Subject(s) - pathology , autopsy , medicine , sarcoma , mesenteric lymph nodes , lung , spleen , lymphoma , gastrointestinal tract , transplantation , lymph , mesentery , immunodeficiency , epithelium , immunology , immune system
A 3 1/2‐year‐old girl with severe combined immunodeficiency received a thymus epithelial graft. After transient clinical and in vitro immunologic improvement, she developed fever, lung infiltrates and, terminally, massive gastrointestinal bleeding only 2 1/2 months after transplantation. Autopsy revealed widespread immunoblastic sarcoma involving both transplantation sites in the mesentery and thigh, lymph nodes, lung, liver, spleen and gastrointestinal tract. This B cell lymphoma was likely induced by the grafted thymus epithelium.