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Morphological patterns of the liver in South American blastomycosis
Author(s) -
TEIXEIRA F.,
GAYOTTO L. C.,
BRITO T.
Publication year - 1978
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1978.tb01716.x
Subject(s) - bile duct , pathology , cholestasis , fibrosis , blastomycosis , medicine , pathogenesis , necrosis , gastroenterology
Histological features were semi‐quantitatively analysed in 60 livers, obtained by necropsy, from patients who died of South American blastomycosis. These findings were classified and correlated with duration of the disease and treatment. Bile‐duct lesions were prominent and a particular pattern was found in which segments of bile ducts were ‘disrupted’ and replaced by inflammatory reaction. A classification of the lesions is proposed: Class o—near normal livers; Class I—predominance of necrosis and suppuration; Class II—predominance of tuberculoid granulomas; Class III—portal fibrosis and non‐specific infiltrate. There has been no evidence that treatment could induce bile‐duct proliferation, fatty change of liver cells, or cholestasis. On the other hand, less fibrosis was found in treated patients. Pathogenesis of the bile‐duct lesions is discussed.