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Morphological aspects of the endocrine pancreas in a prednisolone‐treated infant
Author(s) -
BARRESI G.,
INFERRERA C.,
GEMELLI M.,
LUCA F.
Publication year - 1977
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1977.tb01659.x
Subject(s) - neogenesis , endocrine system , pancreas , enteroendocrine cell , prednisolone , biology , endocrinology , islet , medicine , corticosteroid , hormone , insulin
The endocrine pancreas of a corticosteroid‐treated infant during the course of nephrotic syndrome was morphologically studied. Islet cell hyperpasia and dispersed endocrine cell aggregates betwen acinar tissue were observed. A marked numerical increase of B cells was identified by using cytochemical and immunofluorescent methods. Morphometric data support the morphological observations. The findings suggest that corticosteroid treatment induces endocrine cell replication and neogenesis.