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Detection of neoplastic and preneoplastic urothelia by combined scanning and transmission electron microscopy of urinary surface of human and rat bladders
Author(s) -
NEWMAN J.,
HICKS R. M.
Publication year - 1977
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1977.tb01651.x
Subject(s) - urothelium , urinary bladder , pathology , transitional cell , urothelial cell , biology , electron microscope , transmission electron microscopy , urinary system , transitional cell carcinoma , anatomy , medicine , materials science , bladder cancer , nanotechnology , optics , genetics , physics , cancer
Scanning and transmission electron microscopy reveal distinct differences between the appearance of the luminal surface membrane of normal urothelium and those of transitional cell tumours of both human and rat bladder. The luminal surface membrane of the preneoplastic rat urothelium shows features similar to those seen in the fully developed tumour. In human tumour‐bearing bladders the urothelium away from the transitional cell tumour is not recognizable as being preneoplastic by light microscopy. However, by scanning or transmission electron microscopy, the luminal membrane in some areas shows changes identical to those in the preneoplastic rat bladder. These observations are in accordance with in the clinical behaviour of the urothelium in patients with vesical transitional cell tumours which tend to recur in disparate sites. We suggest that scanning electron microscopy of the bladder urothelium away from the tumour may be of prognostic value for indicating the subsequent biological behaviour of the urothelium