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The Effect of Aspartame on Migraine Headache
Author(s) -
Koehler Shirley M.,
Glaros Alan
Publication year - 1988
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1365-2524.1988.hed2801010.x
Subject(s) - aspartame , migraine , placebo , medicine , ingestion , anesthesia , food science , chemistry , alternative medicine , pathology
SYNOPSIS Recently, three pilot studies have proposed that the addition of products containing aspartame to thediets of migraine headache sufferers may produce a significant increase in the frequency of theirmigraines. The present study was a controlled thirteen‐week, double‐blind, randomized cross‐over studycomparing the effect of aspartame to that of a matched placebo on the frequency and intensity of migraineheadache. The results of this study indicated that the ingestion of aspartame by migraineurs caused asignificant increase in headache frequency for some subjects. The implications of these findings andsuggestions for further research are discussed.