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Difficulties and pitfalls in the laboratory diagnosis of bleeding disorders
Author(s) -
BOLTONMAGGS P. H. B.,
FAVALORO E. J.,
HILLARP A.,
JENNINGS I.,
KOHLER H. P.
Publication year - 2012
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1111/j.1365-2516.2012.02830.x
Subject(s) - medicine , von willebrand disease , pediatrics , intensive care medicine , disease , von willebrand factor , pathology , immunology , platelet
Summary. von Willebrand disease (VWD) is the most common inherited bleeding disorder, but variable severity and several classification types mean that diagnosis is often not straightforward. In many countries, the assays are not readily available and/or are not well standardized. The latest methods and the basis of VWD are discussed here, together with information from the international quality assessment programme (IEQAS). Factor XIII deficiency is a rare, but important bleeding disorder, which may be missed or diagnosed late. A discussion and update on this diagnosis is considered in the final section of our review.