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A case report of an acquired inhibitor to coagulation factor V
Author(s) -
SHANMUGAM H.,
JAYARANEE S.,
EOW G. I.
Publication year - 2011
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1111/j.1365-2516.2010.02342.x
Subject(s) - kuala lumpur , medicine , library science , family medicine , computer science , business , marketing
following strategy for the management of pregnancy in patients with congenital afibrinogenemia: 1. Commence fibrinogen concentrate infusions as soon as pregnancy is confirmed. 2. Ensure a multidisciplinary approach to antenatal care and delivery. 3. Commence with infusions of 2–3 g week in the first and second trimester aiming for trough levels of 0.5 g L and increase quantity as determined by weekly fibrinogen levels. 4. Increase trough fibrinogen concentration to ‡1.0 g L in late 3rd trimester. 5. Administer bolus of fibrinogen concentrate (4 g stat) at start of labour. 6. Start continuous infusion of fibrinogen concentrate aiming for a concentration of 1.5 g L during labour or CS and for 24 h postpartum. A dose of at least 5 g per 24 h is required to maintain this concentration of plasma fibrinogen.