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HCV treatment with pegylated interferon and ribavirin in patients with haemophilia and HIV/HCV co‐infection
Author(s) -
DENHOLM J. T.,
WRIGHT E. J.,
STREET A.,
SASADEUSZ J. J.
Publication year - 2009
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1111/j.1365-2516.2009.01972.x
Subject(s) - ribavirin , medicine , haemophilia , pegylated interferon , hepatitis c virus , hepatitis c , cohort , viral load , haemophilia a , population , immunology , gastroenterology , virology , human immunodeficiency virus (hiv) , pediatrics , virus , environmental health
Summary. Individuals with haemophilia are frequently infected with both human immunodeficiency virus (HIV) and hepatitis C virus (HCV); however, limited evidence is currently available regarding the efficacy of HCV treatment with pegylated interferon and ribavirin in this patient population. The aim of this study was to review HCV treatment outcomes in a cohort of patients with haemophilia and HIV/HCV co‐infection. A retrospective, single centre review of 13 consecutive patients treated with pegylated interferon and ribavirin was performed. All patients were male with haemophilia A and a median age of 43 (range 27–62) at initiation of HCV therapy. Nine of 13 (69%) patients had genotype (gt1) 1 HCV (3 × gt3, 1 × gt4). Twelve of 13 (92%) were receiving ART, with a mean CD4+ count of 428 cells μL −1 (range 175–928 cells μL −1 ) at initiation of HCV therapy. Six of 11 (55%) patients achieved EVR (3 × gt1, 2 × gt3, 1 × gt4) at 12 weeks, 4/13 (31%) had EOTR (2 × gt1, 2 × gt3) and 1/13 (8%) achieved sustained virological response (1 × gt1). Seven of 11 (64%) patients normalized ALT during therapy wherein mean ALT fell from 101 to 76 U L −1 . Only 1/13 (8%) patients discontinued therapy prematurely due to side effects. CD4+ cell counts and HIV viral load remained stable during HCV treatment, with a mean 437 cells μL −1 and <50 copies mL −1 at 48 weeks respectively. Patients in our cohort with haemophilia and HCV/HIV co‐infection responded poorly to HCV treatment. Alternative HCV treatment strategies need to be considered in patients with haemophilia and HIV/HCV co‐infection.