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In vivo models of haemophilia – status on current knowledge of clinical phenotypes and therapeutic interventions
Author(s) -
ØVLISEN K.,
KRISTENSEN A. T.,
TRANHOLM M.
Publication year - 2008
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1111/j.1365-2516.2007.01636.x
Subject(s) - haemophilia , medicine , milestone , psychological intervention , animal model , intensive care medicine , bioinformatics , pediatrics , biology , archaeology , psychiatry , history
Summary. Animal models have contributed immensely to the understanding of and the improvement in treatment of haemophilia A and B. First, establishment of haemophilic dog colonies provided an invaluable opportunity to investigate the diseases and later, the advances in gene technologies resulting in small haemophilic animal models were a milestone in the preclinical research making it possible to address some of the many unanswered questions. This review provides an overview of animal models used in the study of haemophilia as well as a short overview of the contributions resulting from studies in these models.