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Combined clotting factor deficiencies: experience at a single hemophilia treatment center
Author(s) -
O'BRIEN S. H.,
RITCHEY A. K.,
RAGNI M. V.
Publication year - 2007
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1111/j.1365-2516.2006.01389.x
Subject(s) - medicine , haemophilia , clotting factor , von willebrand disease , coagulation , von willebrand factor , incidence (geometry) , single center , pediatrics , population , factor ix , surgery , platelet , physics , environmental health , optics
Summary. We describe a series of patients with combined factor deficiencies and von Willebrand's disease (VWD) at one haemophilia treatment centre. Although the incidence of VWD is at least 1% in the general population, combined coagulation defects have been infrequently described in the medical literature and are likely under diagnosed. This entity should be considered in patients with a known factor deficiency and either an unexpectedly severe bleeding phenotype, or bleeding that is unresponsive to factor replacement.