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Drug dosing in children – special considerations
Author(s) -
PENCHARZ P. B.
Publication year - 2006
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1111/j.1365-2516.2006.01331.x
Subject(s) - lean body mass , medicine , protein metabolism , metabolism , body weight , protein turnover , energy metabolism , physiology , dosing , endocrinology , protein biosynthesis , biology , biochemistry
Summary. During growth the body composition, protein and energy metabolism of children changes. This paper aims to assess these changes as they relate to factors which might affect the metabolism of factor concentrates, through a review of body composition, protein and energy metabolism literature in childhood. Key findings were that protein metabolism is four times higher in neonates and twice as high in infants as compared with adults. In addition the interstitial fluid space in infants and younger children is approximately double that in adults. On the basis that protein metabolism relates most closely to lean body mass, which in turn relates to body weight one can conclude that factor concentrate doses should be based on body weight. We concluded that clearance of protein factor concentrates might be faster in infants and young children due to their higher protein turnover rate.